Henni Jörissen was born in Hamburg in 1986. She studied acting at the Ernst Busch Academy of Dramatic Arts in Berlin.
In 2005, she performed in "Spring Awakening" at the Deutsches Schauspielhaus Hamburg, directed by Nils Daniel Finckh. She made her debut at the Deutsches Theater Berlin as Selma in Gerhart Hauptmann's "The Rats," which was invited to the 2008 Berliner Theatertreffen, followed by a performance in Henrik Ibsen's "The Wild Duck," directed by Michael Thalheimer. Henni Jörissen was awarded the O.E. Hasse Prize in 2007. From 2009 to 2013, she was engaged at the Schauspiel Frankfurt, appearing in productions such as "Faust. First Part," directed by Stefan Pucher, and "Peer Gynt," directed by Antú Romero Nunes. From the 2013 to 2020 season, she was a permanent ensemble member at the Schauspielhaus Zürich, working with directors including Barbara Frey, Antú Nunes Romero, Stefan Pucher, Bastian Kraft, Christopher Rüping, and Nicolas Stemann. Since 2023, she has been performing in Viktor Bodo's "Der Morgenstern," and since February 2024, in "Die gläserne Stadt" at the Deutsches Schauspielhaus Hamburg.